tag:blogger.com,1999:blog-6601092456598994348.post7888496799325539740..comments2023-06-05T09:07:06.848-04:00Comments on Hodge Podge: Finding Normalcy Post-Hodge: Fished my wishDennishttp://www.blogger.com/profile/01568909093366842091noreply@blogger.comBlogger2125tag:blogger.com,1999:blog-6601092456598994348.post-20941989998909532622010-06-16T09:50:29.256-04:002010-06-16T09:50:29.256-04:00Jovanovic D et al
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The idea that antidepressant...Jovanovic D et al<br /><br />.<br />The idea that antidepressants might be effective for cancer was first explored fifty years ago, and ample proof has emerged. To verify, access Medline or Pubmed, and enter “antidepressants” and “cancer.” With patience, you may retrieve more than seventy studies showing that antidepressants destroy cancer cells, inhibit their proliferation, convert multidrug resistant cells to chemotherapy sensitive, protect nonmalignant cells from damage by ionizing radiation and chemotherapy toxicity, and target the mitochondria of cancer cells, while sparing those of healthy ones. Antidepressants can arrest cancer even in advanced stages, occasionally reverse it, significantly extend life, and have shown much promise in malignancies often resistant to chemotherapy and radiation. In 1998, Brenda Penninx showed that at age 70, people who are chronically depressed have an increased risk of cancer of 88%, and an increased risk of dying of it of 50%.<br />Paradigm shifts may not become medical revolutions unless widely disseminated, so as to bypass vested interests. This one could do wonders for people, and for health economics. I have contributed five reviews to the advance.<br /><br />Lieb, J. “Antidepressants, eicosanoids and the prevention and treatment of cancer.” Plefa (2001) 65(5&6), 233-239 <br /><br />Lieb, J. “Antidepressants, prostaglandins and the prevention and treatment of <br />cancer.” Medical Hypotheses (2007) 684-689<br /><br />Lieb, J.”The multifaceted value of antidepressants in cancer therapeutics.” Editorial comment. European Journal of Cancer 44 (2) 2008 172-174 <br /><br />Lieb, J.”Defeating cancer with antidepressants.” Ecancermedicalscience. DOI 10.3332/eCMS.2008.88<br /><br />Lieb, J.”The remarkable anticancer properties of antidepressants.” DOI.10.3332/eCMS.LTR.149<br /><br />An impressive clinical study <br />.Two groups of advanced non-small cell lung cancer (NSCLC) were analyzed and compared: Group A-26 patients (12 treated with chemotherapy –CT, 14 with best supportive care BSC), all receiving 10mg/day of Mianserin and Group B-26 patients with comparable corresponding characteristics, who were treated with chemotherapy.<br />An objective clinical response to chemotherapy was observed in five patients receiving Mianserin, and only two patients who did not receive it. Median survival time for Mianserin patients was also significantly better. A surprising fact emerged in 2 patients with adenocarcinoma: one with local tumor recurrence and diffuse bone metastases, evidently stable with no further progression for 37 months, the other with metastases in the upper mediastinal lymph nodes, with no further progression for 26 months. Symptom control (pain, dyspnea, and emotional functioning) were significantly better in Mianserin Group A. Antidepressants are highly specific and humans variable, thus some of the non responders may well have responded to alternatives to Mianserin.<br /><br />Jovanovic D, et al: Mianserin therapy in advanced lung cancer patients. 8th Central European Lung Cancer Conference. Vienna 2002. Internal Process Division, Monduzzi Editore 2002; 339-343<br /><br />Julian Lieb, M.DAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-6601092456598994348.post-44113538463692478482010-03-08T13:51:45.131-05:002010-03-08T13:51:45.131-05:00Glad to hear things are going well! I am a cancer...Glad to hear things are going well! I am a cancer survivor and I work for ChiliTechnology. The <a href="http://www.chilitechnology.com/" rel="nofollow">ChiliPad</a> is a great invention for people who have medical conditions that make them too hot to sleep - it's a cooling mattress pad. You can set any temp. you want down to 46 degrees. It also heats - if you need that. Unlike the electric blanket it keeps the electromagnetic field far away from the body - so doesn't increase your risk of cancer or get in the way of healing. It really helped me during chemo when I was getting sweats and chills.Rosahttp://www.chilitechnology.com/noreply@blogger.com